Inactivation of the IGF-I receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I.

@article{Froment2007InactivationOT,
  title={Inactivation of the IGF-I receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I.},
  author={Pascal Froment and Mich{\`e}le Vigier and Didier Neg̀re and Isabelle Fontaine and J Beghelli and Francois Luic Cosset and Martin Holzenberger and Phillipe Durand},
  journal={The Journal of endocrinology},
  year={2007},
  volume={194 3},
  pages={557-68}
}
IGF-I regulates pituitary and gonadal functions, and is pivotal for sexual development and fertility in mammalian species. To better understand the function of autocrine IGF-I in Sertoli cell physiology, we established a system for Cre-mediated conditional inactivation of the IGF-I receptor (IGF-IR) in cultured Sertoli cells. We show here that loss of IGF-IR decreased the number of viable Sertoli cells as a consequence of diminished Sertoli cell proliferation and increased Sertoli cell death… CONTINUE READING

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