Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

@article{Esteller2000InactivationOT,
  title={Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.},
  author={Manel Esteller and Jes{\'u}s Miguel Garc{\'i}a-Foncillas and Esther Andion and Steven N. Goodman and Oscar F. Hidalgo and V Vanaclocha and Stephen B. Baylin and James G. Herman},
  journal={The New England journal of medicine},
  year={2000},
  volume={343 19},
  pages={1350-4}
}
BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a promoter; methylation of the promoter silences the gene in cancer, and the cells no longer produce MGMT. We examined gliomas to determine whether methylation of the MGMT promoter is related to the responsiveness of the tumor to alkylating agents. METHODS We analyzed the MGMT promoter in tumor DNA by a methylation-specific… CONTINUE READING
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