Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma.

@article{Maesawa1996InactivationOT,
  title={Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma.},
  author={Chihaya Maesawa and Gen Tamura and Satoshi S Nishizuka and Satoshi Ogasawara and Kaoru Shijyonawate-shi Ishida and Masanori Terashima and Ken Sakata and Noriyuki Sato and Kana Saito and Ryoichi Satodate},
  journal={Cancer research},
  year={1996},
  volume={56 17},
  pages={
          3875-8
        }
}
We examined the genomic status of the CDKN2 gene including de novo methylation of 5' CpG islands in primary and metastatic tumor samples from 31 patients with esophageal squamous cell carcinoma. One somatic frame shift mutation (1 of 31; 3.2%) was identified by PCR-single strand conformational polymorphism analysis and DNA sequencing. Homozygous deletion and de novo methylation of the gene were confirmed in 5 (16%) and 6 (19%) of 31 patients, respectively. Homozygous deletion and de novo… CONTINUE READING

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