Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.

@article{Wicks2000InactivationOS,
  title={Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.},
  author={Stephen J Wicks and Songling Lui and Nadia Abdel-Wahab and Roger Maxwell Mason and Andrew D. Chantry},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 21},
  pages={
          8103-11
        }
}
Members of the transforming growth factor beta (TGF-beta) family transduce signals through Smad proteins. Smad signaling can be regulated by the Ras/Erk/mitogen-activated protein pathway in response to receptor tyrosine kinase activation and the gamma interferon pathway and also by the functional interaction of Smad2 with Ca(2+)-calmodulin. Here we report that Smad-TGF-beta-dependent transcriptional responses are prevented by expression of a constitutively activated Ca(2+)-calmodulin-dependent… CONTINUE READING
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