Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide.

@article{Tolando2001InactivationOR,
  title={Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide.},
  author={Roberto Tolando and Alberta Zanovello and Roberta Ferrara and James N. Iley and Maurizio Manno},
  journal={Toxicology letters},
  year={2001},
  volume={124 1-3},
  pages={101-11}
}
N,N-dimethylformamide (DMF), an organic solvent widely used in industry, is bioactivated by cytochrome P450 (P450) to reactive metabolites which are believed to be responsible for the hepatotoxicity observed in animals and humans. A decrease of the activating enzyme has been reported in rats treated with DMF, although the specific P450 isoform(s) involved and the nature of the reactive species responsible for this and the other toxic effects are still being investigated. In the present work… CONTINUE READING

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