Inactivation of p53 and Pten promotes invasive bladder cancer.

Abstract

Although bladder cancer represents a serious health problem worldwide, relevant mouse models for investigating disease progression or therapeutic targets have been lacking. We show that combined deletion of p53 and Pten in bladder epithelium leads to invasive cancer in a novel mouse model. Inactivation of p53 and PTEN promotes tumorigenesis in human bladder… (More)
DOI: 10.1101/gad.1772909

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