Inactivation of p16 in human mammary epithelial cells by CpG island methylation.

  title={Inactivation of p16 in human mammary epithelial cells by CpG island methylation.},
  author={Scott A. Foster and David J. Wong and Michael T. Barrett and Denise A. Galloway},
  journal={Molecular and cellular biology},
  volume={18 4},
Proliferation of human mammary epithelial cells (HMEC) is limited to a few passages in culture due to an arrest in G1 termed selection or mortality stage 0, M0. A small number of cells spontaneously escape M0, continue to proliferate in culture, and then enter a second mortality stage, M1, at which they senesce. Evidence that M0 involves the Rb pathway comes from the observation that expression of human papillomavirus type 16 E7 alleviates the M0 proliferation block, and we further show that… CONTINUE READING

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