Inactivation of organellar glutamyl- and seryl-tRNA synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants.

@article{Kim2005InactivationOO,
  title={Inactivation of organellar glutamyl- and seryl-tRNA synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants.},
  author={Yu-kyung Kim and Jae-young Lee and Hye-sun Cho and Sang Sook Lee and Hyun Jung Ha and Sunghoon Kim and Doil Choi and Hyun-Sook Pai},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 44},
  pages={37098-106}
}
Aminoacyl-tRNA synthetases (ARSs) are key enzymes involved in protein translation, and both cytosolic and organellar forms are present in the genomes of eukaryotes. In this study, we investigated cellular effects of depletion of organellar forms of ARS using virus-induced gene silencing (VIGS) in Nicotiana benthamiana. VIGS of NbERS and NbSRS, which encode organellar GluRS and SerRS, respectively, resulted in a severe leaf-yellowing phenotype. The NbERS and NbSRS genes were ubiquitously… CONTINUE READING

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