Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells.

@article{Nazari2011InactivationON,
  title={Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells.},
  author={Maryam Nazari and Asghar Ghorbani and Azita Hekmat-Doost and Mahmood Jeddi-Tehrani and Hamid Zand},
  journal={European journal of pharmacology},
  year={2011},
  volume={650 2-3},
  pages={
          526-33
        }
}
Hesperidin, a flavonoid present in fruits and vegetables, possesses anti-inflammatory and chemopreventive effects. Some evidence implies that hesperidin may recruit Peroxisome Proliferator-Activated Receptor-gamma (PPARγ) to exert biological action. It has been shown also that inactivation of Nuclear Factor-kappaB is another mechanism of flavonoids' action. Therefore, we wished to investigate the role of these transcription factors in apoptosis induced by hesperidin in Ramos Burkitt's lymphoma… CONTINUE READING

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