Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus.

  title={Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus.},
  author={Alexey V Ruzin and Anatoly Severin and Soraya L. Moghazeh and J{\^e}rome Etienne and Patricia A Bradford and Steven J. Projan and David M. Shlaes},
  journal={Biochimica et biophysica acta},
  volume={1621 2},
A chemically generated mutant of Staphylococcus aureus RN4220, GC6668, was isolated that had a fourfold increase in resistance to vancomycin. This phenotype reverted back to susceptibility by insertional mutagenesis with Tn917. In a selected set of revertants, Tn917 insertion was mapped to a unique chromosomal region upstream of mprF, a recently described gene that determines staphylococcal resistance to several host defense peptides. The genetic linkage between the vancomycin susceptibility… CONTINUE READING
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