Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.

@article{Park2000InactivationOI,
  title={Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.},
  author={J. S. Park and Esther J Kim and Ho Jeong Kwon and Eun Seong Hwang and Sung Eun Namkoong and S J Um},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 10},
  pages={6764-9}
}
In studying biological roles of interferon regulatory factor (IRF)-1 tumor suppressor in cervical carcinogenesis, we found that HPV E7 is functionally associated with IRF-1. Binding assays indicate a physical interaction between IRF-1 and HPV E7 in vivo and in vitro. The carboxyl-terminal transactivation domain of IRF-1 was required for the interaction. Transient co-expression of E7 significantly inhibits the IRF-1-mediated activation of IFN-beta promoter in NIH-3T3 cells. Co-transfection of E7… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 102 extracted citations

Similar Papers

Loading similar papers…