Inactivation of human white blood cells in platelet products after pathogen reduction technology treatment in comparison to gamma irradiation

@article{Fast2011InactivationOH,
  title={Inactivation of human white blood cells in platelet products after pathogen reduction technology treatment in comparison to gamma irradiation},
  author={Loren D Fast and Gilbert Dileone and Susanne Marschner},
  journal={Transfusion},
  year={2011},
  volume={51}
}
BACKGROUND: During the transfusion of blood products, the transfer of allogeneic donor white blood cells (WBCs) can mediate adverse reactions in recipients. To minimize reactions, blood components are leukoreduced and/or exposed to gamma irradiation. Nucleic acid–targeted pathogen reduction technologies (PRTs) processes are well suited for WBC inactivation. The Mirasol PRT system (CaridianBCT Biotechnologies) uses riboflavin and ultraviolet light to reduce the active pathogen load and… Expand
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