Inactivation of human coagulation factor V by activated protein C.

@article{Suzuki1983InactivationOH,
  title={Inactivation of human coagulation factor V by activated protein C.},
  author={Kiyoshi Suzuki and Johan Stenflo and Bj{\"o}rn Dahlb{\"a}ck and B Teodorsson},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 3},
  pages={
          1914-20
        }
}
Thrombin-activated vitamin K-dependent protein C purified from human plasma has a potent anticoagulant effect on human plasma, whereas its bovine counterpart has a very weak anticoagulant effect on human plasma. This species difference was found to be partly due to a more rapid degradation of human factor Va by human than by bovine activated protein C. In the presence of phospholipid, activated human protein C cleaves several peptide bonds in fragment D (heavy chain of factor Va), whereas in… CONTINUE READING

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