Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.

@article{Xu2001InactivationOH,
  title={Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.},
  author={Xiaohong Xu and Lawren C. Wu and Fei Du and Ashley C Davis and Michael Peyton and Yoshio Tomizawa and Anirban Maitra and Gail Tomlinson and Adi F. Gazdar and Bernard E. Weissman and Anne M Bowcock and Richard D. Baer and John D. Minna},
  journal={Cancer research},
  year={2001},
  volume={61 21},
  pages={7943-9}
}
A cDNA clone encoding human SRBC [serum deprivation response factor (sdr)-related gene product that binds to c-kinase] was isolated in a yeast two-hybrid screening, with amino acids 1-304 of BRCA1 as the probe. The human SRBC gene (hSRBC) was mapped to chromosome region 11p15.5-p15.4, close to marker D11S1323, at which frequent loss of heterozygosity (LOH) has been observed in sporadic breast, lung, ovarian, and other types of adult cancers as well as childhood tumors. hSRBC-coding region… CONTINUE READING

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