Inactivation of fibroblast growth factor receptor signaling in myelinating glial cells results in significant loss of adult spiral ganglion neurons accompanied by age-related hearing impairment.

Abstract

Hearing loss has been attributed to many factors, including degeneration of sensory neurons in the auditory pathway and demyelination along the cochlear nerve. Fibroblast growth factors (FGFs), which signal through four receptors (Fgfrs), are produced by auditory neurons and play a key role in embryonic development of the cochlea and in neuroprotection… (More)
DOI: 10.1002/jnr.22164

Topics

8 Figures and Tables

Cite this paper

@article{Wang2009InactivationOF, title={Inactivation of fibroblast growth factor receptor signaling in myelinating glial cells results in significant loss of adult spiral ganglion neurons accompanied by age-related hearing impairment.}, author={S. J. Wang and Miki Furusho and C D'sa and Scott K. Kuwada and Lisa A Conti and D. Kent Morest and Ravi Bansal}, journal={Journal of neuroscience research}, year={2009}, volume={87 15}, pages={3428-37} }