Inactivation of erythropoietin leads to defects in cardiac morphogenesis.

  title={Inactivation of erythropoietin leads to defects in cardiac morphogenesis.},
  author={Haihong Wu and Seung Hee Lee and Jimin Gao and Xingfeng Liu and M Luisa Iruela-Arispe},
  volume={126 16},
Erythropoietin is an essential growth factor that promotes survival, proliferation, and differentiation of mammalian erythroid progenitor cells. Erythropoietin(-/-) and erythropoietin receptor(-/-) mouse embryos die around embryonic day 13.5 due, in part, to failure of erythropoiesis in the fetal liver. In this study, we demonstrated a novel role of erythropoietin and erythropoietin receptor in cardiac development in vivo. We found that erythropoietin receptor is expressed in the developing… CONTINUE READING