Inactivation of endotoxin by polymyxin B.

  title={Inactivation of endotoxin by polymyxin B.},
  author={Michael S. Cooperstock},
  journal={Antimicrobial agents and chemotherapy},
  volume={6 4},
The limulus gelation assay was utilized to investigate endotoxin inactivation by a number of antibiotics in vitro. Endotoxin activity was sharply reduced by polymyxin B and sodium colistimethate. The effect of the polymyxin was not significantly inhibited by 0.001 M calcium or 90% serum. Crude endotoxins from a variety of aerobic gram-negative bacteria, including several not previously studied, could be inactivated 1 or more logs by as little as 1 mug of polymyxin B per ml, whereas Bacteroides… CONTINUE READING

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