Inactivation of depolarization-induced calcium uptake in rat brain synaptosomes

@article{Hoss2004InactivationOD,
  title={Inactivation of depolarization-induced calcium uptake in rat brain synaptosomes},
  author={W. Hoss and B. Labkovsky},
  journal={Neurochemical Research},
  year={2004},
  volume={11},
  pages={1361-1372}
}
The inactivation of depolarization-induced Ca uptake into rat brain synaptosomes was demonstrated biochemically by comparing45Ca fluxes after various intervals of predepolarization achieved by abruptly increasing {K+}0. The chemical composition of the medium was maintained throughout the predepolarization and Ca uptake steps. Under these conditions, inactivation was dependent on depolarization, i.e., basal unstimulated Ca uptake in the presence of 5 mM {K+}0 did not inactivate. Inactivation of… 

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