Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase.


Chloramphenicol and florfenicol are broad-spectrum antibiotics. Although the bacterial resistance mechanisms to these antibiotics have been well documented, hydrolysis of these antibiotics has not been reported in detail. This study reports the hydrolysis of these two antibiotics by a specific hydrolase that is encoded by a gene identified from a soil… (More)
DOI: 10.1128/AEM.01154-12


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