Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock.

@article{Macarthur2000InactivationOC,
  title={Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock.},
  author={Heather Macarthur and Thomas C. Westfall and Dennis P. Riley and Thomas P. Misko and Daniela Salvemini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 17},
  pages={9753-8}
}
A major feature of septic shock is the development of a vascular crisis characterized by nonresponsiveness to sympathetic vasoconstrictor agents and the subsequent irreversible fall in blood pressure. In addition, sepsis, like other inflammatory conditions, results in a large increase in the production of free radicals, including superoxide anions (O(2)) within the body. Here we show that O(2) reacts with catecholamines deactivating them in vitro. Moreover, this deactivation would appear to… CONTINUE READING
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Pathophysiology and Clinical Application Of Nitric Oxide, ed

  • C. Szabo
  • 1999

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