Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium.

@article{Lee1985InactivationOC,
  title={Inactivation of calcium channels in mammalian heart cells: joint dependence on membrane potential and intracellular calcium.},
  author={Kevin Sang Lee and Eduardo Marb{\'a}n and Richard W. Tsien},
  journal={The Journal of physiology},
  year={1985},
  volume={364},
  pages={395-411}
}
Ca channel currents were recorded in Cs-loaded calf cardiac Purkinje fibres and Cs-dialysed myocytes from guinea-pig ventricle to evaluate the dependence of Ca channel inactivation on membrane depolarization and intracellular free Ca concentration ([Ca]i). The decay of Ca channel current during a maintained depolarization was slowed when external Ca was replaced by Sr or Ba. The decay reflected a genuine inactivation of Ca channel conductance, as assessed by the decreased amplitude of inward… CONTINUE READING
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