Inactivation of atrial natriuretic factor by the renal brush border.

  title={Inactivation of atrial natriuretic factor by the renal brush border.},
  author={G M Olins and Karen L Spear and Norbert Siegel and H. A. Zurcher-Neely},
  journal={Biochimica et biophysica acta},
  volume={901 1},
Atrial natriuretic factor (ANF), a 28-amino-acid peptide secreted from the mammalian heart, is known to be cleared rapidly from the circulation. In vitro and in vivo studies implicate the kidney as an important site for clearance and subsequent degradation of atrial natriuretic factor. We have observed that atrial natriuretic factor is inactivated rapidly by rabbit kidney brush-border membranes. The rate of degradation of ANF measured by the loss of bioactivity followed a similar time-course to… CONTINUE READING


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