Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.

@article{Winder1996InactivationOA,
  title={Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.},
  author={William Winder and David Grahame Hardie},
  journal={The American journal of physiology},
  year={1996},
  volume={270 2 Pt 1},
  pages={E299-304}
}
Malonyl-CoA, an inhibitor of fatty acid oxidation in skeletal muscle mitochondria, decreases in rat skeletal muscle during exercise or in response to electrical stimulation. Regulation of rat skeletal muscle acetyl-CoA carboxylase (ACC), the enzyme that synthesizes malonyl-CoA, was studied in vitro and in vivo. Avidin-Sepharose affinity-purified ACC from hindlimb skeletal muscle was phosphorylated by purified liver AMP-activated protein kinase with a concurrent decrease in ACC activity. AMP… CONTINUE READING
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Time course of the exercise - induced decline in malonyl - CoA in different muscle types

  • W. W. Winder, I. M. Elayan JArogyasami, D. Cartmill
  • Am . J . Physiol . 259 ( Endocrinol . Metab .
  • 1994

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