Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

@article{Zhao2007InactivationOY,
  title={Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.},
  author={Bin Zhao and Xiaomu Wei and Weiquan Li and Ryan S. Udan and Qian Yang and Joungmok Kim and Joe Xie and Tsuneo Ikenoue and Jindan Yu and Li Li and Pan Zheng and Keqiang Ye and Arul M. Chinnaiyan and Georg Halder and Zhi-chun Lai and Kun-Liang Guan},
  journal={Genes & development},
  year={2007},
  volume={21 21},
  pages={
          2747-61
        }
}
The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis in Drosophila. Although recent genetic studies have shown that the Hippo pathway is regulated by the NF2 and Fat tumor suppressors, the physiological regulations of this pathway are unknown. Here we show that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway. Phosphorylation by the Lats tumor suppressor kinase… CONTINUE READING

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