Inactivation of Two Dictyostelium discoideum Genes, DdPIK1 and DdPIK2, Encoding Proteins Related to Mammalian Phosphatidylinositide 3-kinases, Results in Defects in Endocytosis, Lysosome to Postlysosome Transport, and Actin Cytoskeleton Organization

@article{Buczynski1997InactivationOT,
  title={Inactivation of Two Dictyostelium discoideum Genes, DdPIK1 and  DdPIK2, Encoding Proteins Related to Mammalian Phosphatidylinositide  3-kinases, Results in Defects in Endocytosis, Lysosome to Postlysosome  Transport, and Actin Cytoskeleton Organization},
  author={Greg Buczynski and Bryon Grove and Anson Nomura and Maurice Kleve and John G Bush and Richard A. Firtel and James Cardelli},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={136},
  pages={1271 - 1286}
}
Phosphatidylinositide 3-kinases (PI3-kinases) have been implicated in controlling cell proliferation, actin cytoskeleton organization, and the regulation of vesicle trafficking between intracellular organelles. There are at least three genes in Dictyostelium discoideum. DdPIK1, DdPIK2, and DdPIK3, encoding proteins most closely related to the mammalian 110-kD PI-3 kinase in amino acid sequence within the kinase domain. A mutant disrupted in DdPIK1 and DdPIK2 (delta ddpik1/ddpik2) grows slowly… CONTINUE READING
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A role for a Rab4-like GTPase in endocytosis and in regulation of contractile vacuole structure and function in Dictyostelium discoideum

  • J. Bush, L. Temesvari, J. Rodriquez-Paris, G. Buczynski, J. Cardelli.
  • Mol. Biol. Cell. 7:1623–1638.
  • 1996
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