Inactivation of Peroxiredoxin 6 by the Pla Protease of Yersinia pestis.

@article{Zimbler2016InactivationOP,
  title={Inactivation of Peroxiredoxin 6 by the Pla Protease of Yersinia pestis.},
  author={Daniel L. Zimbler and Justin L. Eddy and Jay A. Schroeder and Wyndham W Lathem},
  journal={Infection and immunity},
  year={2016},
  volume={84 1},
  pages={365-74}
}
Pneumonic plague represents the most severe form of disease caused by Yersinia pestis due to its ease of transmission, rapid progression, and high mortality rate. The Y. pestis outer membrane Pla protease is essential for the development of pneumonic plague; however, the complete repertoire of substrates cleaved by Pla in the lungs is not known. In this study, we describe a proteomic screen to identify host proteins contained within the bronchoalveolar lavage fluid of mice that are cleaved and… CONTINUE READING