Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice.

@article{Gao2007InactivationOP,
  title={Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice.},
  author={Zhanguo Gao and Zhong Wang and Xiaoying Zhang and Andrew A. Butler and Aamir R. Zuberi and Barbara Gawronska-Kozak and Michael L Lefevre and David A. York and Eric Ravussin and Hans-Rudolf Berthoud and Owen P. McGuinness and William T. Cefalu and Jianping Ye},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 1},
  pages={E84-91}
}
In this study, we investigated the metabolic phenotype of PKCtheta knockout mice (C57BL/6J) on chow diet and high-fat diet (HFD). The knockout (KO) mice are normal in growth and reproduction. On the chow diet, body weight and food intake were not changed in the KO mice; however, body fat content was increased with a corresponding decrease in body lean mass. Energy expenditure and spontaneous physical activity were decreased in the KO mice. On HFD, energy expenditure and physical activity… CONTINUE READING
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