Inactivation of O6-alkylguanine-DNA alkyltransferase in HeLa cells by cisplatin.

@article{Wang1989InactivationOO,
  title={Inactivation of O6-alkylguanine-DNA alkyltransferase in HeLa cells by cisplatin.},
  author={Lei Wang and Richard B. Setlow},
  journal={Carcinogenesis},
  year={1989},
  volume={10 9},
  pages={1681-4}
}
Inactivation of O6-alkylguanine-DNA alkyltransferase (O6-AGT) in HeLa CCL2 cells by cisplatin was studied. HeLa CCL2 cells treated with cisplatin showed a dose-dependent decline in O6-AGT activity. After cisplatin was removed and replaced with fresh medium, the transferase level began to rise slowly. By 72 h slightly more than 80% of the activity was recovered. It seems that the activity of the alkyltransferase can be inactivated by platinated DNA adducts. The data suggest that the O6-platinum… CONTINUE READING

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