Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection

@article{Collazo2001InactivationOL,
  title={Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection},
  author={Carmen M. Collazo and George S. Yap and Gregory D Sempowski and Kimberly C. Lusby and Lino Tessarollo and George F. Vande Woude and Alan Sher and Gregory Alan Taylor},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={194},
  pages={181 - 188}
}
The cytokine interferon (IFN)-gamma regulates immune clearance of parasitic, bacterial, and viral infections; however, the underlying mechanisms are poorly understood. Recently, a family of IFN-gamma-induced genes has been identified that encode 48-kD GTP-binding proteins that localize to the endoplasmic reticulum of cells. The prototype of this family, IGTP, has been shown to be required for host defense against acute infections with the protozoan parasite Toxoplasma gondii, but not for normal… CONTINUE READING
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