Inactivation of Lgt allows systematic characterization of lipoproteins from Listeria monocytogenes.

@article{Baumgrtner2007InactivationOL,
  title={Inactivation of Lgt allows systematic characterization of lipoproteins from Listeria monocytogenes.},
  author={Maja Baumg{\"a}rtner and Uwe K{\"a}rst and Birgit Gerstel and Martin J Loessner and J{\"u}rgen Wehland and Lothar J{\"a}nsch},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 2},
  pages={313-24}
}
Lipoprotein anchoring in bacteria is mediated by the prolipoprotein diacylglyceryl transferase (Lgt), which catalyzes the transfer of a diacylglyceryl moiety to the prospective N-terminal cysteine of the mature lipoprotein. Deletion of the lgt gene in the gram-positive pathogen Listeria monocytogenes (i) impairs intracellular growth of the bacterium in different eukaryotic cell lines and (ii) leads to increased release of lipoproteins into the culture supernatant. Comparative extracellular… CONTINUE READING