Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9

@inproceedings{HarthHertle2013InactivationOI,
  title={Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9},
  author={Marie L Harth-Hertle and Barbara A. Scholz and Florian Erhard and Laura V Glaser and Lars D{\"o}lken and Ralf Zimmer and Bettina Kempkes},
  booktitle={PLoS pathogens},
  year={2013}
}
Epstein-Barr virus (EBV) causes a persistent infection in human B cells by establishing specific transcription programs to control B cell activation and differentiation. Transcriptional reprogramming of EBV infected B cells is predominantly driven by the action of EBV nuclear antigens, among them the transcriptional repressor EBNA3A. By comparing gene expression profiles of wt and EBNA3A negative EBV infected B cells, we have previously identified a broad array of cellular genes controlled by… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

Chromatin reorganisation in Epstein-Barr virus-infected cells and its role in cancer development.

  • Current opinion in virology
  • 2017
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Epstein-Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexes.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2015
VIEW 5 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 100 REFERENCES

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL