Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement.

@article{Self1994InactivationOG,
  title={Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement.},
  author={David W Self and Rosemarie Terwilliger and Eric J Nestler and Larry Stein},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 10},
  pages={6239-47}
}
The pertussis toxin (PTX)-sensitive G proteins Gi and G(o) may be implicated in drug reinforcement and addiction, since certain reward-related dopamine and opiate receptor subtypes are coupled to these G proteins, and since chronic exposure to cocaine or morphine alters levels of these G proteins in the nucleus accumbens (NAc). As a direct test of this hypothesis, Gi and G(o) proteins in the NAc were selectively inactivated by intra-accumbens injections of PTX in rats self-administering either… CONTINUE READING