Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy

@inproceedings{Girgert2012InactivationOG,
  title={Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy},
  author={Rainer Girgert and Guenter Emons and Carsten Gruendker},
  booktitle={Breast Cancer Research and Treatment},
  year={2012}
}
Triple-negative breast cancers lack estrogen receptor α (ERα), progesterone receptor, and do not overexpress human epidermal growth factor receptor 2 (Her-2). They are neither susceptible to endocrine therapy nor to a therapy using the anti-Her-2 antibody, trastuzumab. Therefore, an efficient targeted therapy is warranted. Triple-negative breast tumors frequently express membrane bound estrogen receptor G-protein coupled receptor (GPR30). As proof of principle, we analyzed the consequences of a… CONTINUE READING
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