Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway.

Abstract

G-protein-coupled receptors (GPCRs), one of the most versatile groups of cell surface receptors, can recognize specific ligands from neural, hormonal, and paracrine organs and regulate cell growth, proliferation, and differentiation. Gpr48/LGR4 is a recently identified orphan GPCR with unknown functions. To reveal the functions of Gpr48 in vivo, we… (More)
DOI: 10.1074/jbc.M800721200

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@article{Song2008InactivationOG, title={Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway.}, author={Huiping Song and Jian Luo and Weijia Luo and Jinsheng Weng and Zhiqiang Wang and Baoxing Li and Dali Li and Mingyao Liu}, journal={The Journal of biological chemistry}, year={2008}, volume={283 52}, pages={36687-97} }