Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.

@article{Danis2015InactivationOE,
  title={Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.},
  author={Etienne Danis and Taylor Yamauchi and Kristen Echanique and Jessica N Haladyna and Roshni S. Kalkur and Simone S. Riedel and Nan Zhu and Huafeng Xie and Kathrin Maria Bernt and Stuart H Orkin and Scott A. Armstrong and Tobias A Neff},
  journal={Experimental hematology},
  year={2015},
  volume={43 11},
  pages={930-935.e6}
}
Polycomb repressive complex 2 (PRC2) is a chromatin regulator with central roles in development and cancer. The canonical function of PRC2 is the trimethylation of histone 3 on lysine residue 27. This epigenetic modification is associated with gene silencing. Both tumor suppressor and oncogenic functions have been reported for PRC2, depending on cellular context. In leukemia mediated by the leukemogenic fusion MLL-AF9, complete ablation of canonical PRC2 function by genetic inactivation of the… CONTINUE READING
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