Inactivation of BLU is associated with methylation of Sp1-binding site of BLU promoter in gastric cancer.

  title={Inactivation of BLU is associated with methylation of Sp1-binding site of BLU promoter in gastric cancer.},
  author={Kunting Xiao and Zhuwen Yu and Dong-tao Shi and Zhe Lei and Hongbing Chen and Jian Cao and Wen-yan Tian and Weichang Chen and Hong-Tao Zhang},
  journal={International journal of oncology},
  volume={47 2},
BLU is a candidate tumor suppressor gene, which is epigenetically inactivated in many human malignancies. However, the expression and biological functions of BLU in gastric cancer has not yet been reported. In the present study, we identified a functional BLU promoter which was regulated by the transcription activator Sp1. Bisulfite sequencing and qRT-PCR assays indicated that the silence of BLU expression in gastric cancer was significantly associated with DNA hypermethylation of BLU promoter… 

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