Inactivation of 14-3-3 sigma by promoter methylation correlates with metastasis in nasopharyngeal carcinoma.

@article{Yi2009InactivationO1,
  title={Inactivation of 14-3-3 sigma by promoter methylation correlates with metastasis in nasopharyngeal carcinoma.},
  author={Bin Yi and Shuang-xiang Tan and Can-e Tang and Wei-guo Huang and Ai-lan Cheng and Cui Li and Pengfei Zhang and Maoyu Li and Jian-ling Li and Hong Yi and Fang Peng and Zhuchu Chen and Zhi-qiang Xiao},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={106 5},
  pages={858-66}
}
14-3-3 sigma, the downstream target of p53, is a negative regulator of cell cycle G2-M phase checkpoint in response to DNA damage. Our previous comparative proteomics study showed that 14-3-3 sigma was downregulated or lost in nasopharyngeal carcinoma (NPC) tissue compared with non-cancerous nasopharyngeal epithelial tissue (NNET). In this study, we further investigated for the epigenetic mechanism of 14-3-3 sigma inactivation. Methylation-specific PCR showed 14-3-3 sigma promoter methylation… CONTINUE READING

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References

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Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004
View 4 Excerpts
Highly Influenced

High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 4 Excerpts
Highly Influenced

Patterns of distant metastases in nasopharyngeal carcinoma.

The Kaohsiung journal of medical sciences • 1996
View 2 Excerpts
Highly Influenced

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