Inactivation of [Leu5]-enkephalin in three isolated preparations: relative importance of aminopeptidase, endopeptidase-24.11 and peptidyl dipeptidase A.

@article{Oka1986InactivationO,
  title={Inactivation of [Leu5]-enkephalin in three isolated preparations: relative importance of aminopeptidase, endopeptidase-24.11 and peptidyl dipeptidase A.},
  author={Toru Oka and Kozo Aoki and Makoto Kajiwara and Kaori Ishii and Yuichiro Kuno and Toyokazu Hiranuma and Teruhiko Matsumiya},
  journal={NIDA research monograph},
  year={1986},
  volume={75},
  pages={259-62}
}
Enkephalin had been shown to be almost exclusively hydrolyzed by three peptidases in the previous studies. In the present investigation, the relative importance of three enzymes in the inactivation of [Leu5]-enkephalin was examined in three isolated preparations. Results showed that amastatin-sensitive aminopeptidase played the greatest role in both guinea… CONTINUE READING