Inactivation in HCN Channels Results from Reclosure of the Activation Gate Desensitization to Voltage

  title={Inactivation in HCN Channels Results from Reclosure of the Activation Gate Desensitization to Voltage},
  author={Ki Soon Shin and Chantal Maertens and Catherine Proenza and Brad S Rothberg and Gary Yellen},
Hyperpolarization-activated HCN channels are modulated by direct binding of cyclic nucleotides. For HCN2 channels, cAMP shifts the voltage dependence for activation, with relatively little change in the maximal conductance. By contrast, in spHCN channels, cAMP relieves a rapid inactivation process and produces a large increase in maximum conductance. Our results suggest that these two effects of cAMP represent the same underlying process. We also find that spHCN inactivation occurs not by… CONTINUE READING
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The pipette solution ( extracellular ) was Physiol

  • D. T. Liu, H. Yao, D. Bartsch, E. R. Kandel, G. R. Tibbs
  • 2003

Mechanism of glutamate receptor desensitization . the Belgian American Educational Foundation ( to C . M . )

  • G. Yellen
  • Nature
  • 2002

The tionactivated cation current in neurons

  • H. C. Pape, D. A. McCormick
  • Annu . Rev . Physiol .
  • 2001

Identification of a gene encoding a negative voltages ( Malcolm et al . , 2003 ) . Bath solution : 140 KCl , hyperpolarizationactivated pacemaker channel of brain

  • A. Aruffo
  • 1998

Queer current and pacemaker : the hyperpolarizato increase functional expression levels

  • H. C. Pape
  • 1996
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