Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling.

@article{Chouinard2008InactivationBU,
  title={Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling.},
  author={Sarah Chouinard and M F Yueh and Robert H. Tukey and Franck Giton and Jean Fiet and Georges Pelletier and Olivier Barbier and Alain B{\'e}langer},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2008},
  volume={109 3-5},
  pages={247-53}
}
Conjugation by UDP-Glucuronosyltransferase (UGT) is the major pathway of androgen metabolism and elimination in the human. High concentrations of glucuronide conjugates of androsterone (ADT) and androstane-3alpha,17beta-diol (3alpha-diol) are present in circulation and several studies over the last 30 years have concluded that the serum levels of these metabolites might reflect the androgen metabolism in several tissues, including the liver and androgen target tissues. Three UGT2B enzymes are… CONTINUE READING

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References

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Showing 1-10 of 66 references

Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population

  • H. Nakazato Okugi, H. Matsui, N. Ohtake, S. Nakata, K. Suzuki
  • Cancer Detect . Prev .
  • 2006

Isoform - specific regulation of UDP - glucuronosyltransferase ( UGT ) 2 B enzymes in the human prostate : differential consequences for androgen and bioactive lipid inactivation

  • G. Pelletier Chouinard, A. Belanger, O. Barbier
  • Endocrinology
  • 2006

Struc - tural and functional studies of UDP - glucuronosyltransferases

  • P. J. Czernik Radominska-Pandya, J. M. Little, E. Battaglia, P. I. Mackenzie
  • DrugMetab . Rev .
  • 2005

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