Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

@article{Li2011InactivatingMO,
  title={Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma},
  author={Meng Li and Hong Lei Zhao and Xiaosong Zhang and Laura D Wood and Robert Albert Anders and Michael A. Choti and Timothy M Pawlik and Hubert D.-J. Daniel and Rajesh Kannangai and George Johan Arnold Offerhaus and Victor E. Velculescu and Linfang Wang and Shibin Zhou and Bert Vogelstein and Ralph H. Hruban and Nick Papadopoulos and Jianqiang Cai and Michael S. Torbenson and Kenneth W. Kinzler},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={828-829}
}
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting… CONTINUE READING
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