Inactivating mutations block the tumor necrosis factor-alpha-converting enzyme in the early secretory pathway.

Abstract

The ectodomain of different transmembrane molecules is released by a proteolytic event known as shedding. The metalloprotease disintegrin proTNF-alpha converting enzyme (TACE) is responsible for the shedding of various proteins, including protransforming growth factor-alpha (proTGF-alpha) and amyloid-beta precursor protein (APP). Inactive TACE accumulates… (More)

Topics

  • Presentations referencing similar topics