Inactivating mutation of the pro-apoptotic gene BID in gastric cancer.

@article{Lee2004InactivatingMO,
  title={Inactivating mutation of the pro-apoptotic gene BID in gastric cancer.},
  author={Jong Heun Lee and Young Hwa Soung and Jong Woo Lee and Won Sang Park and Su Young Kim and Yong Gu Cho and Chang Jae Kim and Si Hyung Seo and Hong Sug Kim and Suk Woo Nam and Nam Jin Yoo and Sug Hyung Lee and Jung Young Lee},
  journal={The Journal of pathology},
  year={2004},
  volume={202 4},
  pages={
          439-45
        }
}
There is evidence that deregulation of apoptosis is mechanistically involved in cancer development and somatic mutations of apoptosis-related genes have been reported in human cancers. BID, a pro-apoptotic member of the Bcl-2 family, interconnects the extrinsic apoptosis pathway initiated by death receptors to the intrinsic apoptosis pathway. To explore the possibility that genetic alterations of BID might be involved in the development of human cancers, this study analysed the entire coding… CONTINUE READING
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