Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression.

@article{Saffert2006InactivatingAC,
  title={Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression.},
  author={Ryan T. Saffert and Robert F Kalejta},
  journal={Journal of virology},
  year={2006},
  volume={80 8},
  pages={3863-71}
}
Human cytomegalovirus (HCMV) masterfully evades adaptive and innate immune responses, allowing infection to be maintained and periodically reactivated for the life of the host. Here we show that cells also possess an intrinsic immune defense against HCMV that is disarmed by the virus. In HCMV-infected cells, the promyelocytic leukemia nuclear body (PML-NB) protein Daxx silences viral immediate-early gene expression through the action of a histone deacetylase. However, this antiviral tactic is… CONTINUE READING
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Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-depen 3870 SAFFERT AND KALEJTA

  • R. F. Kalejta, J. T. Bechtel, T. Shenk
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