Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells.

@article{Rahmanto2016InactivatingAT,
  title={Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells.},
  author={Yohan Suryo Rahmanto and Jin-Gyoung Jung and Ren-Chin Wu and Yusuke Kobayashi and Christopher M Heaphy and Alan K Meeker and Tian-Li Wang and Ie-Ming Shih},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 18},
  pages={
          9690-9
        }
}
ARID1A is a tumor suppressor gene that belongs to the switch/sucrose non-fermentable chromatin remodeling gene family. It is mutated in many types of human cancer with the highest frequency in endometrium-related ovarian and uterine neoplasms including ovarian clear cell, ovarian endometrioid, and uterine endometrioid carcinomas. We have previously reported that mutations in the promoter of human telomerase reverse transcriptase (TERT) rarely co-occur with the loss of ARID1A protein expression… CONTINUE READING
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