Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus.

@article{Weber2003InactivatedPO,
  title={Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus.},
  author={Olaf Weber and Angela Siegling and Astrid Friebe and Andreas Limmer and Tobias Schlapp and P. J. Knolle and Andrew Mercer and Heinz Schaller and H P Volk},
  journal={The Journal of general virology},
  year={2003},
  volume={84 Pt 7},
  pages={1843-52}
}
It is known that some viruses are able to induce vigorous immune reactions. This study shows that inactivated parapoxvirus ovis (Orf virus), strain D1701 (PPVO), induces an autoregulatory cytokine response that involves the upregulation of IL-12, IL-18, IFN-gamma and other T helper 1-type cytokines and their subsequent downregulation, which is accompanied by induction of IL-4. An increase in IL-10 expression was also found in the livers of PPVO-treated mice. PPVO protects mice from lethal… CONTINUE READING