Inactivated meningococci and pertussis bacteria are immunogenic and act as mucosal adjuvants for a nasal inactivated influenza virus vaccine.

@article{Berstad2000InactivatedMA,
  title={Inactivated meningococci and pertussis bacteria are immunogenic and act as mucosal adjuvants for a nasal inactivated influenza virus vaccine.},
  author={Aud Katrine Herland Berstad and S. R. Andersen and R Dalseg and S Dromtorp and Johan Holst and Ellen Namork and Elisabeth Wedege and Bj\orn Haneberg},
  journal={Vaccine},
  year={2000},
  volume={18 18},
  pages={1910-9}
}
Whole killed meningococci (Nm) and pertussis bacteria (Bp) were tested for mucosal immunogenicity and as mucosal adjuvants for an inactivated influenza virus vaccine given intranasally to unanaesthetized mice. Virus was given alone, or simply mixed with one of the bacterial preparations, in four doses at weekly intervals. The virus alone induced low but significant increases of influenza-specific IgG antibodies in serum measured by ELISA, whereas IgA responses in serum and saliva were… CONTINUE READING