Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.

@article{Kurooka2007InactivatedSV,
  title={Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.},
  author={Masayuki Kurooka and Yasufumi Kaneda},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={
          227-36
        }
}
UV-inactivated, replication-defective Sendai virus particles [hemagglutinating virus of Japan envelope (HVJ-E)] injected into murine colon carcinoma (CT26) tumors growing in syngeneic BALB/c mice eradicated 60% to 80% of the tumors and obviously inhibited the growth of the remainder. Induced adaptive antitumor immune responses were dominant in the tumor eradication process because the effect was abrogated in severe combined immunodeficient mice. Murine and human dendritic cells underwent dose… 

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