Inaccurate measurement of free carnitine by the electrospray tandem mass spectrometry screening method for blood spots

@article{Johnson1999InaccurateMO,
  title={Inaccurate measurement of free carnitine by the electrospray tandem mass spectrometry screening method for blood spots},
  author={David W Johnson},
  journal={Journal of Inherited Metabolic Disease},
  year={1999},
  volume={22},
  pages={201-202}
}
An increasing number of laboratories screen for inherited metabolic diseases by electrospray tandem mass spectrometric analysis of extracts of blood spots from newborns (Chace et al 1995 ; Rashed et al 1995). The dried methanol extract of the blood spot, to which deuterium-labelled internal standards have been added, is butylated and infused into an electrospray tandem mass spectrometer. The concentrations of carnitine, acylcarnitines and amino acids are measured and compared with a normal… CONTINUE READING

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