Inability of divalent cation complexes of A23187 to induce platelet secretion.


Extracellular calcium produces a dose-dependent inhibition of the early time course of A23187-induced 14C-5HT secretion in human platelets which is independent of the occurrence of aggregation. Pre-incubation of A23187 with calcium to form the A23187-Ca complex results in markedly prolonged lag periods prior to the onset of secretion at Ca concentrations of… (More)


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